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You can be sure that our team will do their best to make the test book read online for free the most successful accomplishment of your life., 297-314) and lymphocyte invasion and activation is associated with enhanced virus replication, thus supporting a role for IFN induction in limiting CVB3 replication.
It is well known that IFN-α acts on hepatocytes and other cells to induce the Mx1 gene and stimulate an antiviral state associated with the accumulation of PKR in the cell nucleus, but IFN-α is much more potently antiviral for some cell types than for others. The effectiveness of IFN-α in preventing human hepatitis A virus (HAV) infection is, for example, very limited and an effective dose of IFN-α is associated with significant toxicity (Herz and Tomas, 1993, Virol., 160, 210-221). Mice infected with SV40 were protected from tumor formation (Sato, N., et al., 1975, J. Natl. Cancer Inst., 55, 753-759) and mice injected with murine leukemia virus (MuLV) were not infected with the virus (Denker, S. L., 1979, Nature, 284, 663-665) as a consequence of IFN induction.
Interferon γ is also used in the treatment of tumors and has been implicated in the pathogenesis of numerous human neoplasias, such as chronic my
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